Giovanni Gotte Selected Research

ranpirnase (Pannon)

6/2022	Role of the Ribonuclease ONCONASE in miRNA Biogenesis and tRNA Processing: Focus on Cancer and Viral Infections.
1/2022	Upregulation of miR-34a-5p, miR-20a-3p and miR-29a-3p by Onconase in A375 Melanoma Cells Correlates with the Downregulation of Specific Onco-Proteins.
11/2019	Onconase Restores Cytotoxicity in Dabrafenib-Resistant A375 Human Melanoma Cells and Affects Cell Migration, Invasion and Colony Formation Capability.
1/2019	Influence of onconase in the therapeutic potential of PARP inhibitors in A375 malignant melanoma cells.
11/2017	Onconase dimerization through 3D domain swapping: structural investigations and increase in the apoptotic effect in cancer cells.
3/2015	Onconase induces autophagy sensitizing pancreatic cancer cells to gemcitabine and activates Akt/mTOR pathway in a ROS-dependent manner.

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Giovanni Gotte Research Topics

Disease

11	Neoplasms (Cancer) 06/2022 - 04/2010
6	Melanoma (Melanoma, Malignant) 01/2022 - 06/2003
3	Pancreatic Neoplasms (Pancreatic Cancer) 01/2019 - 05/2014
1	Virus Diseases (Viral Diseases) 06/2022
1	Hypoxia (Hypoxemia) 01/2022
1	Neurodegenerative Diseases (Neurodegenerative Disease) 09/2021
1	Parkinson Disease (Parkinson's Disease) 02/2021
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 02/2021
1	Mesothelioma 01/2019
1	Asthma (Bronchial Asthma) 01/2018
1	Pneumonia (Pneumonitis) 01/2018
1	Adenocarcinoma 03/2015
1	Amyloid Plaque 11/2013

Drug/Important Bio-Agent (IBA)

6	ranpirnase (Pannon)IBA 06/2022 - 03/2015
6	Proteins (Proteins, Gene)FDA Link 01/2022 - 11/2013
3	Ribonucleases (Ribonuclease)IBA 06/2022 - 01/2019
3	Pancreatic Ribonuclease (Ribonuclease A)IBA 05/2014 - 06/2003
2	MicroRNAs (MicroRNA)IBA 06/2022 - 01/2022
2	Cytostatic AgentsIBA 01/2022 - 11/2021
2	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 11/2019 - 01/2018
2	Pharmaceutical PreparationsIBA 01/2019 - 03/2015
2	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2019 - 01/2018
2	Biological ProductsIBA 01/2019 - 11/2013
2	EnzymesIBA 01/2018 - 05/2014
2	CytokinesIBA 01/2018 - 10/2016
1	Antiviral Agents (Antivirals)IBA 06/2022
1	Transfer RNA (tRNA)IBA 06/2022
1	Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA 06/2022
1	Phosphotransferases (Kinase)IBA 01/2022
1	Tyrosine (L-Tyrosine)FDA Link 11/2021
1	angiogeninIBA 09/2021
1	AgarIBA 11/2019
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 11/2019
1	Gentian Violet (Violet, Crystal)FDA Link 11/2019
1	dabrafenibIBA 11/2019
1	Bromodeoxyuridine (BrdU)IBA 11/2019
1	AZD2461IBA 01/2019
1	olaparibIBA 01/2019
1	Alkylating AgentsIBA 01/2019
1	DNA (Deoxyribonucleic Acid)IBA 01/2019
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 01/2019
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2019
1	Therapeutic UsesIBA 01/2019
1	STAT6 Transcription FactorIBA 01/2018
1	InterleukinsIBA 01/2018
1	Interleukin-5 (Interleukin 5)IBA 01/2018
1	Adrenergic Agonists (Adrenergic Receptor Agonist)IBA 01/2018
1	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2018
1	Interleukin-13IBA 01/2018
1	ChemokinesIBA 01/2018
1	HeterochromatinIBA 10/2016
1	MTOR InhibitorsIBA 03/2015
1	Reactive Oxygen Species (Oxygen Radicals)IBA 03/2015
1	Gemcitabine FDA Link 03/2015
1	ribonuclease SPLIBA 05/2014
1	PolyethyleneimineIBA 04/2010

Therapy/Procedure

4	Therapeutics 01/2019 - 03/2015
1	Drug Therapy (Chemotherapy) 03/2015